Document Report Card
Basic Information
ID: ALA1137179
Journal: Bioorg Med Chem Lett
Title: Discovery of inhibitors of human adipocyte fatty acid-binding protein, a potential type 2 diabetes target.
Authors: Lehmann F, Haile S, Axen E, Medina C, Uppenberg J, Svensson S, Lundbäck T, Rondahl L, Barf T.
Abstract: Low micromolar human A-FABP inhibitors were found by utilizing a fluorescence polarization assay, X-ray crystallography and modeling. The carbazole- and indole-based inhibitors displayed approximately 10-fold preferences over human H-FABP and E-FABP, and are highly selective against I-FABP. This communication describes the SAR for drug-like synthetic inhibitors of human A-FABP.
CiteXplore: 15357969