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ID: ALA1137191
Journal: Bioorg Med Chem Lett
Title: Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase.
Authors: Shankaran K, Donnelly KL, Shah SK, Guthikonda RN, MacCoss M, Humes JL, Pacholok SG, Grant SK, Kelly TM, Wong KK.
Abstract: Syntheses and evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase (NOS) are discussed. An extensive SAR was established for pyrrolidin-2-imines class of compounds. The amidines came out as the most potent inhibitors in addition to displaying selectivity.
CiteXplore: 15357988