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ID: ALA1137193
Journal: Bioorg Med Chem Lett
Title: Discovery of new chemical leads for prostaglandin D2 receptor antagonists.
Authors: Torisu K, Kobayashi K, Iwahashi M, Egashira H, Nakai Y, Okada Y, Nanbu F, Ohuchida S, Nakai H, Toda M.
Abstract: A series of Indomethacin analogs were synthesized and biologically evaluated. Among the compounds tested, N-(p-butoxy)benzoyl-2-methylindole-4-acetic acid 2 was discovered as a new chemical lead for a prostaglandin D2 (PGD2) receptor antagonist. Structure-activity relationship data are also presented.
CiteXplore: 15357992