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ID: ALA1137267
Journal: Bioorg Med Chem Lett
Title: Novel aminobenzimidazoles as selective MCH-R1 antagonists for the treatment of metabolic diseases.
Authors: Sasikumar TK, Qiang L, Burnett DA, Greenlee WJ, Hawes BE, Kowalski TJ, O'Neill K, Spar BD, Weig B.
Abstract: A series of novel aminobenzimidazoles was prepared and evaluated for h-MCH-R1 antagonist properties. Most of the compounds showed excellent h-MCH-R1 binding affinity as well as mouse ex vivo binding. Compounds 9 and 18 were active in mouse DIO studies at 30mpk.
CiteXplore: 16889961