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ID: ALA1137274
Journal: Bioorg Med Chem Lett
Title: Discovery and synthesis of tetrahydroindolone-derived carbamates as Kv1.5 blockers.
Authors: Fluxe A, Wu S, Sheffer JB, Janusz JM, Murawsky M, Fadayel GM, Fang B, Hare M, Djandjighian L.
Abstract: A novel class of tetrahydroindolone-derived carbamates has been discovered whose members are potent Kv1.5 blockers. The in vitro data show that compounds 6 and 29 are quite potent. They are also very selective over hERG (>450-fold) and L-type calcium channels (>450-fold).
CiteXplore: 16942878