Document Report Card
Basic Information
ID: ALA1137278
Journal: Bioorg Med Chem Lett
Title: Aza-stilbenes as potent and selective c-RAF inhibitors.
Authors: McDonald O, Lackey K, Davis-Ward R, Wood E, Samano V, Maloney P, Deanda F, Hunter R.
Abstract: The synthesis of several novel aza-stilbene derivatives was carried out. The compounds were tested for their c-RAF enzyme inhibition. Compound 27 possesses significant potency against c-RAF and demonstrates selectivity over other protein kinases. A hypothesis for the binding mode, activity, and selectivity is proposed.
CiteXplore: 16890436