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ID: ALA1137282
Journal: Bioorg Med Chem Lett
Title: Synthesis and structural activity relationship of 11beta-HSD1 inhibitors with novel adamantane replacements.
Authors: Yeh VS, Kurukulasuriya R, Madar D, Patel JR, Fung S, Monzon K, Chiou W, Wang J, Jacobson P, Sham HL, Link JT.
Abstract: A series of structurally novel and metabolically stable bridged bicyclic carbocycle and heterocycle adamantane replacements have been synthesized and biologically evaluated. Several of these compounds exhibit excellent human and mouse 11beta-HSD1 potency and 11beta-HSD2 selectivity.
CiteXplore: 16890427