Document Report Card
Basic Information
ID: ALA1137283
Journal: Bioorg Med Chem Lett
Title: Synthesis and biological evaluation of heterocycle containing adamantane 11beta-HSD1 inhibitors.
Authors: Yeh VS, Patel JR, Yong H, Kurukulasuriya R, Fung S, Monzon K, Chiou W, Wang J, Stolarik D, Imade H, Beno D, Brune M, Jacobson P, Sham H, Link JT.
Abstract: A series of metabolically stable adamantane amide 11beta-HSD1 inhibitors have been synthesized and biologically evaluated. These compounds exhibit excellent HSD1 potency and HSD2 selectivity and good pharmacokinetic and pharmacodynamic profiles.
CiteXplore: 16899366