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ID: ALA1137287
Journal: Bioorg Med Chem Lett
Title: Peptidyl-urea based inhibitors of soluble epoxide hydrolases.
Authors: Morisseau C, Newman JW, Tsai HJ, Baecker PA, Hammock BD.
Abstract: We prepared a series of amino acid derived cyclohexyl and adamantyl ureas and tested them as inhibitors of the human soluble epoxide hydrolase, and obtained very potent compounds (K(I)=15nM) that are >10-fold more soluble than previously described sEH inhibitors. While our lead compound 2 showed low apparent bioavailability in dogs and rats, this series of compounds revealed that sEH inhibitor structures could accept large groups that could lead to better orally available drugs.
CiteXplore: 16908134