7-Aroyl-aminoindoline-1-sulfonamides as a novel class of potent antitubulin agents.
Basic Information
ID: ALA1137315
Journal: J Med Chem
Title: 7-Aroyl-aminoindoline-1-sulfonamides as a novel class of potent antitubulin agents.
Authors: Chang JY, Hsieh HP, Chang CY, Hsu KS, Chiang YF, Chen CM, Kuo CC, Liou JP.
Abstract: A novel series of 7-aroyl-aminoindoline-1-benzenesulfonamides showed excellent activity as inhibitors of tubulin polymerization through binding with the colchicine binding site of microtubules. Compound 15 and 16 display IC50 values of 1.1 and 1.2 microM, respectively. Compound 15 inhibited the human cancer cell growth of KB, MKN45, H460, HT29, and TSGH, as well as one human-resistant cancer line of KB-vin 10, with an IC50 of 9.6, 8.8, 9.4, 8.6, 10.8, and 8.9 nM, respectively.
CiteXplore: 17154496
DOI: 10.1021/jm061076u
Patent ID: ┄