Document Report Card

ID: ALA1137319

Journal: J Med Chem

Title: Thyroid receptor ligands. 6. A high affinity "direct antagonist" selective for the thyroid hormone receptor.

Authors: Koehler K, Gordon S, Brandt P, Carlsson B, Bäcksbro-Saeidi A, Apelqvist T, Agback P, Grover GJ, Nelson W, Grynfarb M, Färnegårdh M, Rehnmark S, Malm J.

Abstract: A new high-affinity thyroid hormone antagonist 6 with druglike properties was designed and synthesized. The compound behaved as an antagonist in a cell transactivation assay, and in a first in vivo experiment in rats.

CiteXplore: 17154490

DOI: 10.1021/jm060521i