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ID: ALA1137464
Journal: Bioorg Med Chem Lett
Title: Novel steroidal saponins, Sch 725737 and Sch 725739, from a marine starfish, Novodinia antillensis.
Authors: Yang SW, Chan TM, Buevich A, Priestley T, Crona J, Reed J, Wright AE, Patel M, Gullo V, Chen G, Pramanik B, Chu M.
Abstract: Bioassay-guided fractionation of an active fraction from an extract of a marine starfish, Novodinia antillensis, led to the isolation and identification of two new saponins, Sch 725737 (1) and Sch 725739 (2). Compound 1 was identified as the NaV1.8 inhibitor with IC(50) of approximately 9 microM. The purification and the structure elucidation of these two saponins are described.
CiteXplore: 17804230