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ID: ALA1137510
Journal: Bioorg Med Chem Lett
Title: Discovery of potent T-type calcium channel blocker.
Authors: Seo HN, Choi JY, Choe YJ, Kim Y, Rhim H, Lee SH, Kim J, Joo DJ, Lee JY.
Abstract: The intensive SAR study of 3,4-dihydroquinazoline series led to the most potent compound 10 (KYS05090: IC(50)=41+/-1 nM) against T-type calcium channel and its potency is nearly comparable to that of Kurtoxin. As a small organic molecule, this compound showed the highest blocking activity reported to date.
CiteXplore: 17869104