Synthesis and biological activities of quinazoline derivatives with ortho-phenol-quaternary ammonium salt groups.

ID: ALA1137513

Journal: Bioorg Med Chem

Title: Synthesis and biological activities of quinazoline derivatives with ortho-phenol-quaternary ammonium salt groups.

Authors: Zhang L, Ren L, Bai M, Weng L, Huang J, Wu L, Deng M, Zhou X.

Abstract: One phenol-quaternary ammonium salt derivative with a flexible linker and three derivatives with a quinazoline moiety are present. Their binding affinities for DNA are discussed and it is clearly demonstrated that this class of phenol-quaternary ammonium salt derivatives could inhibit DNA transcription effectively.

CiteXplore: 17869120

DOI: 10.1016/j.bmc.2007.07.053

Patent ID: ┄