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ID: ALA1137544
Journal: Bioorg Med Chem
Title: Syntheses of immunomodulating androstanes and stigmastanes: comparison of their TNF-alpha inhibitory activity.
Authors: Ramírez JA, Bruttomesso AC, Michelini FM, Acebedo SL, Alché LE, Galagovsky LR.
Abstract: In a previous work our group showed that some synthetic stigmastanes may play a role in immune-mediated inflammation. In this paper we report the syntheses of a series of new steroidal compounds derived from dehydroepiandrosterone and stigmasterol, and the evaluation of their in vitro inhibitory activity of the TNF-alpha production by macrophages. A preliminary qualitative structure-activity relationship was established.
CiteXplore: 17892941