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ID: ALA1137597
Journal: Bioorg Med Chem Lett
Title: Evolution of thiazolidine-based blockers of human Kv1.5 for the treatment of atrial arrhythmias.
Authors: Jackson CM, Blass B, Coburn K, Djandjighian L, Fadayel G, Fluxe AJ, Hodson SJ, Janusz JM, Murawsky M, Ridgeway JM, White RE, Wu S.
Abstract: Blockade of the Kv1.5 ion channel is a potentially atrial-selective avenue for the treatment of atrial fibrillation and atrial flutter. The development and biological evaluation of a series of thiazolidine-based blockers of Kv1.5 is described.
CiteXplore: 17095219