Document Report Card

ID: ALA1137640

Journal: Antimicrob Agents Chemother

Title: In vitro antimycobacterial spectrum of a diarylquinoline ATP synthase inhibitor.

Authors: Huitric E, Verhasselt P, Andries K, Hoffner SE.

Abstract: The diarylquinoline R207910 is in clinical development for tuberculosis treatment. The MIC(50) for 41 drug-susceptible and 44 multidrug-resistant Mycobacterium tuberculosis clinical isolates was 0.032 microg/ml. Out of 20 additional mycobacterial species, three were found to be naturally resistant to R207910 and were shown to exhibit a polymorphism in their atpE genes.

CiteXplore: 17709466

DOI: 10.1128/aac.00181-07