Synthesis, antimicrobial and cytotoxic activities of 1,3,4-oxadiazoles, 1,3,4-thiadiazoles and 1,2,4-triazoles.
Basic Information
ID: ALA1137737
Journal: Eur J Med Chem
Title: Synthesis, antimicrobial and cytotoxic activities of 1,3,4-oxadiazoles, 1,3,4-thiadiazoles and 1,2,4-triazoles.
Authors: Padmavathi V, Sudhakar Reddy G, Padmaja A, Kondaiah P, Ali-Shazia.
Abstract: A new class of 1,3,4-oxadiazoles were prepared from acid hydrazides on treatment with different carboxylic acids in the presence of phosphorus oxychloride. Interconversion of oxadiazoles to thiadiazoles and triazoles was carried out with appropriate reagents. The antimicrobial and cytotoxic activities of compounds 7a-d to 12a-d were tested. Compounds 10d and 12d showed pronounced antimicrobial activity. Further, compound 10d exhibited maximum cytotoxicity.
CiteXplore: 19036476
DOI: 10.1016/j.ejmech.2008.10.012
Patent ID: ┄