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ID: ALA1137754
Journal: Bioorg Med Chem Lett
Title: Inhibitors of potassium channels KV1.3 and IK-1 as immunosuppressants.
Authors: Pegoraro S, Lang M, Dreker T, Kraus J, Hamm S, Meere C, Feurle J, Tasler S, Prütting S, Kuras Z, Visan V, Grissmer S.
Abstract: New structural classes of K(V)1.3 and IK-1 ion channel blockers have been identified based on a virtual high throughput screening approach using a homology model of KcsA. These compounds display inhibitory effects on T-cell and/or keratinocyte proliferation and immunosuppressant activity within a DTH animal model.
CiteXplore: 19282171