Document Report Card

ID: ALA1137803

Journal: J Nat Prod

Title: A novel anti-HIV macrocyclic peptide from Palicourea condensata.

Authors: Bokesch HR, Pannell LK, Cochran PK, Sowder RC, McKee TC, Boyd MR.

Abstract: A 37 amino acid cyclic polypeptide has been isolated from the organic extract of the tropical tree Palicourea condensata. Palicourein (1) is the largest of a growing family of plant peptides that contain a cyclized amino acid backbone cross-linked via three internal disulfide bridges. Palicourein inhibits the in vitro cytopathic effects of HIV-1RF infection of CEM-SS cells with an EC50 value of 0.1 microM and an IC50 value of 1.5 microM.

CiteXplore: 11430013

DOI: 10.1021/np000372l