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ID: ALA1137830
Journal: Bioorg Med Chem Lett
Title: Synthesis and evaluation of tacrine-E2020 hybrids as acetylcholinesterase inhibitors for the treatment of Alzheimer's disease.
Authors: Shao D, Zou C, Luo C, Tang X, Li Y.
Abstract: Tacrine-E2020 hybrids and some related compounds were prepared and their bioactivities on the Alzheimer's disease were assayed. The optimum hybrid inhibitor 3 is 37-fold more potent and 31-fold more selective than tacrine in vitro.
CiteXplore: 15324879