Peptidyl aldehydes as slow-binding inhibitors of dual-specificity phosphatases.

Basic Information

ID: ALA1137841

Journal: Bioorg Med Chem Lett

Title: Peptidyl aldehydes as slow-binding inhibitors of dual-specificity phosphatases.

Authors: Park J, Fu H, Pei D.

Abstract: Peptidyl aldehydes were tested for inhibition of dual-specificity phosphatases VH1 and VHR. The most potent compound, cinnamaldehyde-Gly-Glu-Glu (Cinn-GEE), acted as a slow-binding inhibitor with K(I)* values of 18 and 288 microM against VH1 and VHR, respectively.

CiteXplore: 14741269

DOI: 10.1016/j.bmcl.2003.11.027

Patent ID: ┄

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