Synthesis of C8-linked pyrrolo[2,1-c][1,4]benzodiazepine-benzimidazole conjugates with remarkable DNA-binding affinity.

ID: ALA1137859

Journal: Bioorg Med Chem Lett

Title: Synthesis of C8-linked pyrrolo[2,1-c][1,4]benzodiazepine-benzimidazole conjugates with remarkable DNA-binding affinity.

Authors: Kamal A, Ramulu P, Srinivas O, Ramesh G, Kumar PP.

Abstract: Two types of benzimidazoles have been synthesized and linked to DC-81 at C8-position through different alkyl chain spacers. These PBD conjugates have exhibited remarkable DNA-binding affinity, and a representative compound shows promising in vitro anticancer activity.

CiteXplore: 15324909

DOI: 10.1016/j.bmcl.2004.06.069

Patent ID: ┄