Novel pyrazinone inhibitors of mast cell tryptase: synthesis and SAR evaluation.

Basic Information

ID: ALA1137861

Journal: Bioorg Med Chem Lett

Title: Novel pyrazinone inhibitors of mast cell tryptase: synthesis and SAR evaluation.

Authors: Hopkins C, Neuenschwander K, Scotese A, Jackson S, Nieduzak T, Pauls H, Liang G, Sides K, Cramer D, Cairns J, Maignan S, Mathieu M.

Abstract: In this manuscript, the synthesis and SAR evaluation of a novel pyrazinone class of tryptase inhibitors is described. Chemical optimization of the P1 and P4 groups led to the identification of 7p (K(i)=93 nM) as a potent inhibitor of mast cell tryptase.

CiteXplore: 15341931

DOI: 10.1016/j.bmcl.2004.07.051

Patent ID: