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ID: ALA1137928
Journal: Bioorg Med Chem Lett
Title: Plasmepsin II inhibition and antiplasmodial activity of Primaquine-Statine 'double-drugs'.
Authors: Romeo S, Dell'Agli M, Parapini S, Rizzi L, Galli G, Mondani M, Sparatore A, Taramelli D, Bosisio E.
Abstract: Statine-based inhibitors of Plasmepsin II (PLMII) coupled with Primaquine have been designed using the 'double-drug' approach. The IC50 values for PLMII inhibition ranged from 0.59 to 400 nM and the best IC50 value for inhibition of Plasmodium falciparum growth in vitro was 0.4 microM, which represent a remarkable improvement compared to other statine-based PLMII inhibitors.
CiteXplore: 15125962