Document Report Card

Basic Information

ID: ALA1137928

Journal: Bioorg Med Chem Lett

Title: Plasmepsin II inhibition and antiplasmodial activity of Primaquine-Statine 'double-drugs'.

Authors: Romeo S, Dell'Agli M, Parapini S, Rizzi L, Galli G, Mondani M, Sparatore A, Taramelli D, Bosisio E.

Abstract: Statine-based inhibitors of Plasmepsin II (PLMII) coupled with Primaquine have been designed using the 'double-drug' approach. The IC50 values for PLMII inhibition ranged from 0.59 to 400 nM and the best IC50 value for inhibition of Plasmodium falciparum growth in vitro was 0.4 microM, which represent a remarkable improvement compared to other statine-based PLMII inhibitors.

CiteXplore: 15125962

DOI: 10.1016/j.bmcl.2004.03.030