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ID: ALA1137930
Journal: Bioorg Med Chem Lett
Title: Critical structural motif for the catalytic inhibition of human topoisomerase II by UK-1 and analogs.
Authors: Wang BB, Maghami N, Goodlin VL, Smith PJ.
Abstract: Three new analogs of UK-1 have been synthesized and their efficacies as topoisomerase II inhibitors have been determined. Results show that UK-1 and two of these analogs are catalytic inhibitors of topo II and identifies a critical structure motif necessary for enzyme inhibition.
CiteXplore: 15149679