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ID: ALA1137948
Journal: Bioorg Med Chem Lett
Title: The design and synthesis of sulfonamides as caspase-1 inhibitors.
Authors: Harter WG, Albrect H, Brady K, Caprathe B, Dunbar J, Gilmore J, Hays S, Kostlan CR, Lunney B, Walker N.
Abstract: A series of sulfonamides (1) has been prepared as inhibitors of interleukin-1beta converting enzyme (ICE), also known as caspase 1. These compounds were designed to improve potency by rigidifying the enzyme bound molecule through an intramolecular hydrogen bond. An X-ray crystal structure of a representative member of this series bound to the active site of ICE, confirms the presence of the hydrogen bonding interaction.
CiteXplore: 14741295