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ID: ALA1137985
Journal: Bioorg Med Chem Lett
Title: Synthesis and enzymatic evaluation of xanthine oxidase-activated prodrugs based on inhibitors of thymidine phosphorylase.
Authors: Reigan P, Gbaj A, Chinje E, Stratford IJ, Douglas KT, Freeman S.
Abstract: A series of xanthine oxidase-activated prodrugs of known inhibitors of thymidine phosphorylase has been designed and synthesised to introduce tumour selectivity. These prodrugs were oxidised by xanthine oxidase at C-2 and/or C-4 of the uracil ring to generate the desired TP inhibitor.
CiteXplore: 15454205