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ID: ALA1137993
Journal: Bioorg Med Chem Lett
Title: Novel histone deacetylase inhibitors: cyclic tetrapeptide with trifluoromethyl and pentafluoroethyl ketones.
Authors: Jose B, Oniki Y, Kato T, Nishino N, Sumida Y, Yoshida M.
Abstract: Cyclic tetrapeptides containing trifluoromethyl and pentafluoroethyl ketone as zinc binding functional group were synthesized as potent HDAC inhibitors. Evaluation by human HDAC inhibition assay and p21 promoter assay showed that these inhibitors are promising anticancer agents.
CiteXplore: 15454224