Azaadamantane benzamide 5-HT4 agonists: gastrointestinal prokinetic SC-54750.

ID: ALA1138016

Journal: Bioorg Med Chem Lett

Title: Azaadamantane benzamide 5-HT4 agonists: gastrointestinal prokinetic SC-54750.

Authors: Becker DP, Flynn DL, Shone RL, Gullikson G.

Abstract: Azaadamantanone 1 was converted to a series of aminoazaadamantane benzamides 9a-d, which were profiled for serotonin receptor activity. Aminomethylazaadamantane SC-54750 is a potent 5-HT(4) agonist and 5-HT(3) antagonist with in vivo efficacy in gastroparesis models and also inhibits cisplatin-induced emesis.

CiteXplore: 15482914

DOI: 10.1016/j.bmcl.2004.09.005

Patent ID: ┄