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ID: ALA1138024
Journal: Bioorg Med Chem Lett
Title: Aryl urea analogs with broad-spectrum antibacterial activity.
Authors: Seth PP, Ranken R, Robinson DE, Osgood SA, Risen LM, Rodgers EL, Migawa MT, Jefferson EA, Swayze EE.
Abstract: The preparation and evaluation of novel aryl urea analogs as broad-spectrum antibacterial agents is described. Numerous compounds showed low micromolar minimum inhibitory concentrations (MIC) against both Gram-positive and Gram-negative bacteria. Selected analogs also exhibited in vivo efficacy in a lethal murine model of bacterial septicemia.
CiteXplore: 15482926