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ID: ALA1138069
Journal: Bioorg Med Chem Lett
Title: Synthesis and SAR of 1,3-disubstituted cyclohexylmethyl urea and amide derivatives as non-peptidic motilin receptor antagonists.
Authors: Johnson SG, Gunnet JW, Moore JB, Miller W, Wines P, Rivero RA, Combs D, Demarest KT.
Abstract: A series of 1,3-disubstituted cyclohexylmethyl urea and amide derivatives were synthesized as motilin receptor antagonists. Starting from known motilin antagonists, 1a and 1b, the cyclopentene scaffold was replaced and the four recognition elements optimized to arrive at a potent novel series.
CiteXplore: 16650762