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ID: ALA1138104
Journal: Bioorg Med Chem Lett
Title: Isolation, structure elucidation, antioxidative and immunomodulatory properties of two novel dihydrocoumarins from Aloe vera.
Authors: Zhang XF, Wang HM, Song YL, Nie LH, Wang LF, Liu B, Shen PP, Liu Y.
Abstract: Two new dihydrocoumarin derivatives, compounds 1 and 2, were isolated from Aloe vera. Their structures were determined by X-ray crystallographic diffraction analysis and extensive 1D, 2D NMR spectroscopic data. Both of them evidently showed antioxidant activity against superoxide and hydroxyl radicals. Only 1 obviously exhibited immunomodulatory activity in relation to increasing the phagocytic activity and stimulating the production of superoxide anions in the oxygen respiratory burst of rat peritoneal macrophages.
CiteXplore: 16297615