Document Report Card
Basic Information
ID: ALA1138139
Journal: Bioorg Med Chem Lett
Title: Synthesis of 1-(3',4',5'-trimethoxy) phenyl naphtho[2,1b]furan as a novel anticancer agent.
Authors: Srivastava V, Negi AS, Kumar JK, Faridi U, Sisodia BS, Darokar MP, Luqman S, Khanuja SP.
Abstract: 3',4',5'-Trimethoxy benzoyl-naphthalene 2-O-acetic acid (5) underwent base catalysed intramolecular condensation to yield exclusively 1-(3',4',5'-trimethoxy) phenyl naphtho[2,1-b]furan 8. The cyclised product 8 has been characterised by spectroscopy. The product 8 showed significant anticancer activity against human cancer cell lines COLO320DM (colon), CaCO2 (colon) and WRL68 (liver) at 0.7, 0.65 and 0.50 microg/ml concentrations, respectively, in the in vitro MTT assay.
CiteXplore: 16297622