Asymmetric synthesis of the L-fuco-nojirimycin, a nanomolar alpha-L-fucosidase inhibitor.

ID: ALA1138167

Journal: Bioorg Med Chem Lett

Title: Asymmetric synthesis of the L-fuco-nojirimycin, a nanomolar alpha-L-fucosidase inhibitor.

Authors: Dubernet M, Defoin A, Tarnus C.

Abstract: We describe the asymmetric synthesis of the 5-amino-5-deoxy-l-fucose (l-fuco-nojirimycin) which appears as a very potent fucosidase inhibitor with a K(i) value of 1 nM.

CiteXplore: 16376079

DOI: 10.1016/j.bmcl.2005.11.100

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