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ID: ALA1138168
Journal: Bioorg Med Chem Lett
Title: Imidazo[1,2-a]pyrimidines as functionally selective GABA(A) ligands.
Authors: Blackaby WP, Atack JR, Bromidge F, Castro JL, Goodacre SC, Hallett DJ, Lewis RT, Marshall GR, Pike A, Smith AJ, Street LJ, Tattersall DF, Wafford KA.
Abstract: Imidazo[1,2-a]pyrimidines are GABA(A) receptor benzodiazepine binding site ligands which can exhibit functional selectivity for the alpha(3) subtype over the alpha(1) subtype. SAR studies to optimize this functional selectivity are described.
CiteXplore: 16406613