Synthesis and biological evaluation of photoaffinity labeled fusidic acid analogues.
Basic Information
ID: ALA1138173
Journal: J Med Chem
Title: Synthesis and biological evaluation of photoaffinity labeled fusidic acid analogues.
Authors: Riber D, Venkataramana M, Sanyal S, Duvold T.
Abstract: Novel photoaffinity labeled fusidic acid analogues were obtained by a synthetic sequence employing a Wittig reaction between a fusidic acid aldehyde and benzyl bromides in the key step. Three commonly used photoreactive groups, benzophenone, trifluoromethyldiazirine, and aryl azide, were used. The photoaffinity labeled fusidic acid analogues demonstrated a potent antibacterial activity (MIC 0.016-4 microg/mL) and therefore represent a potential tool for the elucidation of the interactions between fusidic acid and its receptor EF-G.
CiteXplore: 16509567
DOI: 10.1021/jm050583t
Patent ID: ┄