Document Report Card

ID: ALA1138330

Journal: J Med Chem

Title: Total synthesis and absolute configuration of laurenditerpenol: a hypoxia inducible factor-1 activation inhibitor.

Authors: Chittiboyina AG, Kumar GM, Carvalho PB, Liu Y, Zhou YD, Nagle DG, Avery MA.

Abstract: The absolute stereo structure of the natural product laurenditerpenol (1S, 6R, 7S, 10R, 11R, 14S, 15R) has been accomplished from eight plausible stereoisomers by its first asymmetric total synthesis in a highly convergent and flexible synthetic pathway. Six stereoisomers of laurenditerpenol were synthesized and evaluated for their biological activity.

CiteXplore: 18004798

DOI: 10.1021/jm7011062