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ID: ALA1138395

Journal: Bioorg Med Chem Lett

Title: Adamantane sulfone and sulfonamide 11-beta-HSD1 Inhibitors.

Authors: Sorensen B, Winn M, Rohde J, Shuai Q, Wang J, Fung S, Monzon K, Chiou W, Stolarik D, Imade H, Pan L, Deng X, Chovan L, Longenecker K, Judge R, Qin W, Brune M, Camp H, Frevert EU, Jacobson P, Link JT.

Abstract: Potent and selective adamantane sulfone and sulfonamide inhibitors of 11-beta-HSD-1 have been discovered. Selected compounds from these series have robust pharmacokinetic profiles and strongly inhibit liver, fat, and brain HSD1 for extended periods after oral dosing.

CiteXplore: 17070044

DOI: 10.1016/j.bmcl.2006.10.008