Synthesis and DNA-binding ability of C2R-fluoro substituted DC-81 and its dimers.

ID: ALA1138426

Journal: Bioorg Med Chem Lett

Title: Synthesis and DNA-binding ability of C2R-fluoro substituted DC-81 and its dimers.

Authors: Kamal A, Rajasekhar Reddy D, Murali Mohan Reddy PS.

Abstract: C2R-Fluoro substituted DC-81 and its dimers have been synthesized that exhibit significant DNA-binding ability, particularly the five carbon alkane spacer compound (6c) showed the helix melting temperature (DeltaTm) of 18.8 degrees C after incubation of 36 h at 37 degrees C.

CiteXplore: 17113291

DOI: 10.1016/j.bmcl.2006.10.070

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