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ID: ALA1138461
Journal: Bioorg Med Chem Lett
Title: 4-Phenyl-7-azaindoles as potent and selective IKK2 inhibitors.
Authors: Liddle J, Bamborough P, Barker MD, Campos S, Cousins RP, Cutler GJ, Hobbs H, Holmes DS, Ioannou C, Mellor GW, Morse MA, Payne JJ, Pritchard JM, Smith KJ, Tape DT, Whitworth C, Williamson RA.
Abstract: The synthesis and SAR of a novel series of IKK2 inhibitors are described. Modification around the hinge binding region of the 7-azaindole led to a series of potent and selective inhibitors with good cellular activity.
CiteXplore: 19349179