New Labdane diterpenes as intestinal alpha-glucosidase inhibitor from antihyperglycemic extract of Hedychium spicatum (Ham. Ex Smith) rhizomes.
Basic Information
ID: ALA1138603
Journal: Bioorg Med Chem Lett
Title: New Labdane diterpenes as intestinal alpha-glucosidase inhibitor from antihyperglycemic extract of Hedychium spicatum (Ham. Ex Smith) rhizomes.
Authors: Prabhakar Reddy P, Tiwari AK, Ranga Rao R, Madhusudhana K, Rama Subba Rao V, Ali AZ, Suresh Babu K, Madhusudana Rao J.
Abstract: Phytochemical investigation of antihyperglycemic extract of rhizomes of Hedychium spicatum led to the isolation of two new labdane type diterpenes 2, 3 along with seven known compounds (1, 4-9). Their structures were established on the basis of NMR (1D and 2D) and mass spectroscopic analysis. The new compound 2 displayed strong intestinal alpha-glucosidase inhibitory activity. Other compounds also displayed varying degree of intestinal alpha-glucosidase inhibitory potential.
CiteXplore: 19332371
DOI: 10.1016/j.bmcl.2009.03.045
Patent ID: ┄