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ID: ALA1138608
Journal: Bioorg Med Chem Lett
Title: The discovery of potent, selective, and orally bioavailable PDE9 inhibitors as potential hypoglycemic agents.
Authors: Deninno MP, Andrews M, Bell AS, Chen Y, Eller-Zarbo C, Eshelby N, Etienne JB, Moore DE, Palmer MJ, Visser MS, Yu LJ, Zavadoski WJ, Michael Gibbs E.
Abstract: Starting from a non-selective pyrazolo-pyrimidone lead, the sequential use of parallel medicinal chemistry and directed synthesis led to the discovery of potent, highly selective, and orally bioavailable PDE9 inhibitors. The availability of these tools allowed for a thorough evaluation of the therapeutic potential of PDE9 inhibition.
CiteXplore: 19339180