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Basic Information

ID: ALA1138609

Journal: Bioorg Med Chem Lett

Title: Amiloride derived inhibitors of acid-sensing ion channel-3 (ASIC3).

Authors: Kuduk SD, Di Marco CN, Chang RK, Dipardo RM, Cook SP, Cato MJ, Jovanovska A, Urban MO, Leitl M, Spencer RH, Kane SA, Bilodeau MT, Hartman GD, Bock MG.

Abstract: A series of amiloride derivatives modified at the 5-position of the pyrazine ring were evaluated as inhibitors of acid-sensing ion channel-3 (ASIC3), a novel target for the treatment of chronic pain.

CiteXplore: 19339181

DOI: 10.1016/j.bmcl.2009.03.029