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ID: ALA1138609
Journal: Bioorg Med Chem Lett
Title: Amiloride derived inhibitors of acid-sensing ion channel-3 (ASIC3).
Authors: Kuduk SD, Di Marco CN, Chang RK, Dipardo RM, Cook SP, Cato MJ, Jovanovska A, Urban MO, Leitl M, Spencer RH, Kane SA, Bilodeau MT, Hartman GD, Bock MG.
Abstract: A series of amiloride derivatives modified at the 5-position of the pyrazine ring were evaluated as inhibitors of acid-sensing ion channel-3 (ASIC3), a novel target for the treatment of chronic pain.
CiteXplore: 19339181