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ID: ALA1138651
Journal: Bioorg Med Chem Lett
Title: Synthesis of small molecule CDC25 phosphatases inhibitors.
Authors: Contour-Galcéra MO, Lavergne O, Brezak MC, Ducommun B, Prévost G.
Abstract: A targeted library of small molecules has been prepared to optimize the biological activity of BN82002, our initial lead compound, recently described as an original inhibitor of CDC25 phosphatases. Some of these compounds inhibit CDC25 in the micromolar range and therefore reinforce the interest of CDC25 as an anticancer target.
CiteXplore: 15501045