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ID: ALA1138693
Journal: Bioorg Med Chem Lett
Title: Synthesis and biological evaluation of piperazine-based derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1).
Authors: Ye B, Chou YL, Karanjawala R, Lee W, Lu SF, Shaw KJ, Jones S, Lentz D, Liang A, Tseng JL, Wu Q, Zhao Z.
Abstract: Compound 2 was identified by high throughput screening as a novel PAI-1 inhibitor. Systematic optimization of the A, B, and C segments of 2 resulted in the identification of a more potent compound 39 with good oral bioavailability. The synthesis and SAR data are presented in this report.
CiteXplore: 14741285