Document Report Card

ID: ALA1138754

Journal: J Med Chem

Title: Synthesis of taxoids with improved cytotoxicity and solubility for use in tumor-specific delivery.

Authors: Miller ML, Roller EE, Zhao RY, Leece BA, Ab O, Baloglu E, Goldmacher VS, Chari RV.

Abstract: To develop effective taxane-antibody immunoconjugates, we have prepared a series of modified taxanes that have both improved toxicity and solubility in aqueous systems as compared to paclitaxel (1a). These taxanes have been modified at either the C-10 or C-7 position and were found to be very cytotoxic against both normal and multi-drug-resistant (MDR) cells, as well as up to 30 times more soluble than paclitaxel in various buffer systems.

CiteXplore: 15369381

DOI: 10.1021/jm049705s