Document Report Card

ID: ALA1138833

Journal: J Med Chem

Title: Enantioselective synthesis and biological activity of (3S,4R)- and (3S,4S)-3-hydroxy-4-hydroxymethyl- 4-butanolides in relation to PGE2.

Authors: Miranda PO, Estévez F, Quintana J, García CI, Brouard I, Padrón JI, Pivel JP, Bermejo J.

Abstract: Compounds 9 and 13 were synthesized, and their structures and stereochemistry were elucidated by spectroscopic methods. In competition binding experiments, specific [(3)H]-PGE(2) binding was significantly displaced by compound 9 and, to a lesser extent, by 13, in a dose-dependent manner. The biological properties of compound 9 were studied on HL-60 cells, and several effects were found related to those of PGE(2). Compound 9 increases c-fos mRNA level as does PGE(2) and antagonizes TPA-induced terminal differentiation.

CiteXplore: 14711302

DOI: 10.1021/jm034216y