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ID: ALA1138893
Journal: Bioorg Med Chem Lett
Title: Modulators of the human CCR5 receptor. Part 3: SAR of substituted 1-[3-(4-methanesulfonylphenyl)-3-phenylpropyl]-piperidinyl phenylacetamides.
Authors: Cumming JG, Brown SJ, Cooper AE, Faull AW, Flynn AP, Grime K, Oldfield J, Shaw JS, Shepherd E, Tucker H, Whittaker D.
Abstract: SAR and PK studies led to the identification of N-(1-{(3R)-3-(3,5-difluorophenyl)-3-[4-methanesulfonylphenyl] propyl}piperidin-4-yl)-N-ethyl-2-[4-methanesulfonylphenyl]acetamide as a highly potent and selective ligand for the human CCR5 chemokine receptor with good oral pharmacokinetic properties.
CiteXplore: 16631366