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ID: ALA1138927
Journal: Bioorg Med Chem Lett
Title: Neurotrophic peptide aldehydes: solid phase synthesis of fellutamide B and a simplified analog.
Authors: Schneekloth JS, Sanders JL, Hines J, Crews CM.
Abstract: A combination of solid phase and solution phase synthetic methods have been used to complete the total synthesis of the neurotrophic lipopeptide aldehyde fellutamide B (2). The beta-hydroxy aliphatic tail was prepared by regioselective reductive opening of a cyclic sulfate, and later coupled to a solid phase resin. The synthetic compound was then examined in cytotoxicity and nerve growth factor (NGF) induction assays. A simplified analog of fellutamide B also showed activity.
CiteXplore: 16697191