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ID: ALA1138927

Journal: Bioorg Med Chem Lett

Title: Neurotrophic peptide aldehydes: solid phase synthesis of fellutamide B and a simplified analog.

Authors: Schneekloth JS, Sanders JL, Hines J, Crews CM.

Abstract: A combination of solid phase and solution phase synthetic methods have been used to complete the total synthesis of the neurotrophic lipopeptide aldehyde fellutamide B (2). The beta-hydroxy aliphatic tail was prepared by regioselective reductive opening of a cyclic sulfate, and later coupled to a solid phase resin. The synthetic compound was then examined in cytotoxicity and nerve growth factor (NGF) induction assays. A simplified analog of fellutamide B also showed activity.

CiteXplore: 16697191

DOI: 10.1016/j.bmcl.2006.04.029